|(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-三羟基-2-甲基-6,8-双(甲胺基)十氢-4H-苯并[b]吡拉诺[2,3-e][1,4]二氧杂环己烷基-4-一氯化氢五水合物|CsnPharm

CAS No.: 22189-32-8

盐酸大观霉素五水合物 Catalog No. CSN13751

Synonyms: Spectinomycin hydrochloride hydrate;Spectinomycin HCl Hydrate;Spectinomycin (hydrochloride hydrate)

Spectinomycin 2HCl 5H2O used to treat African trypanosomiasis, leishmaniasis, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function.

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400-920-2911

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生物活性

描述Spectinomycin (Dihydrochloride Pentahydrate) is a broad-spectrum aminocyclitol antibiotic that is highly effective in the treatment of uncomplicated gonorrhea. It is a good alternative drug in the treatment of penicillin-allergic patients^[3]. Aminomethyl spectinomycins are active against Gram-negative and Gram-positive bacterial pathogens. Aminomethyl spectinomycins are promising new candidates for development of therapeutics against biodefense bacterial agents^[4]. Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli. However, spectinomycin is not bactericidal and causes no detectable misreading of polyribonucleotides^[5]. The kinetic analysis demonstrated that spectinomycin acts as a mixed noncompetitive inhibitor for the td (T4 thymidylate synthase gene) intron RNA with a K(i) of 7.2 mM. Increasing the spectinomycin concentration raised the K(m) values with the corresponding decrease of V(max) and k(cat) values^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0188 mL
- 10.0939 mL
- 20.1878 mL
- 5 mM
- 0.4038 mL
- 2.0188 mL
- 4.0376 mL
- 10 mM
- 0.2019 mL
- 1.0094 mL
- 2.0188 mL

技术信息

CAS号

22189-32-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H36Cl2N2O12

运输

蓝冰

分子量

495.35

别名

Spectinomycin hydrochloride hydrate;Spectinomycin HCl Hydrate;Spectinomycin (hydrochloride hydrate);Spectinomycin HCl;M-141;Spectinomycin hydrochloride;盐酸大观霉素五水合物

溶解度

DMSO	225.0 mg/mL (454.2 mM)
Water	75.0 mg/mL (151.4 mM)

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